Posts Tagged ‘Human African trypanosomiasis:’

More good news – New test may improve diagnosis of African sleeping sickness

September 19th, 2011

By: Alanna Shaikh

When I was a kid, I thought sleeping sickness sounded like a nice thing to get. Compared to chicken pox or Coxsackie virus, a disease that just made me nod off sounded pleasant. Kind of cozy in a way. Every time I got bored I could just take a little nap, and all the grown-ups would say “Don’t mind her, she has the sleeping sickness.” It would be like being a kitten or a puppy.

Long-time readers of this blog know just how wrong I was. Sleeping sickness is awful. It does not involve a lot of comfy naps. Sleeping sickness – trypanosomiasis – is a deadly parasitic disease transmitted by the tsetse fly.[i] It’s called the world’s deadliest disease.

One especially tricky thing about trypanosomiasis is that it’s very hard to diagnose. The symptoms are varied, and look a lot like the symptoms of everything else. Red sore from the fly bite, fever, headache, irritability. It sounds a lot like ordinary life until it worsens into an infection of the central nervous symptom and then kills you.

The disease actually has no specific clinical symptoms; you have to have a diagnostic test or you’re just guessing. Right now, health workers identify suspected cases of sleeping sickness by looking at symptoms; then they do a spine puncture to draw out fluid and look at it under a microscope to see if the trypanosomiasis parasite is present. It’s a lengthy process that depends on good clinical skills, functional microscopes, and staff with the ability to use them.

Prompt and accurate diagnosis is important to treating trypanosomiasis. The treatment is toxic, for one thing, so you need to be sure it really is sleeping sickness before you treat someone. You can’t treat on a guess. The treatment is also not very effective, so your likelihood of a cure really improves if you fight the infection early. » Read more: More good news — New test may improve diagnosis of African sleeping sickness

Adoption of the Luanda Declaration at the Second Inter-Ministerial Conference on Health and Environment

November 29th, 2010

By: Alanna Shaikh

On Friday November 26, the Second Inter-Ministerial Conference on Health and Environment in Africa came to a close. The 46 countries that attended adopted a declaration – the Luanda declaration – that lays out future health and environmental priorities. It looks like good news for the fight against NTDs.

The list of priorities, honestly, looks like pretty much everything that has to do with health and the environment: “…provision of safe drinking water; Provision of sanitation and hygiene services; Management of environmental and health risks related to climate change; Sustainable management of forests and wetland and Management of water, soil and air pollution as well as biodiversity conservation.

Other priorities are Vector Control and management of chemicals, particularly pesticides and wastes; Food safety and security, including the management of genetically-modified organisms in food productions; Children’s health and women’s environmental health; Health in the workplace and the Management of natural and human-induced disasters.”

Looking deeper, though, it is very interesting what made the list. We’ve done well, within the limitations of global financial support to NTDs, with the medical approach to eliminating the diseases. Mass drug administration, health care provider training, research into vaccines and better treatments. There has been an impressive amount of progress considering the small funding pool. (But no, that does not mean we can stop calling them neglected. NTD programs are good at making do, but wow they could do a lot more with some serious financial support.)

We’ve done less well on addressing the social and environmental determinants of the NTDs. It’s more complex in a lot of ways, and it’s been simpler to focus on medicine. However, we’re not going to treat our way out of the NTDs. We need to look at transmission and context. That’s where this declaration fits in. It reads like a set of WHO guidelines on battling neglected tropical diseases, and that is a very good thing.

» Read more: Adoption of the Luanda Declaration at the Second Inter-Ministerial Conference on Health and Environment

Climate Change and the Spread of Vector-Borne Diseases

September 30th, 2010

By: John O. Davies-Cole, PhD, MPH, Professor at The George Washington University

A vector-borne disease is one in which an arthropod or other agent is responsible for transmitting a pathogen or disease-causing organism like, bacteria, virus or protozoa  from an infected individual to another individual.  According to the World Health Organization (WHO), the most deadly vector-borne disease, malaria, kills over 1.2 million people annually, mostly African children under the age of five, and dengue fever, together with associated dengue hemorrhagic fever (DHF), is the world’s fastest growing vector borne disease.  Nearly half of the world’s population suffers from vector-borne diseases, resulting in high morbidity and mortality. The most seriously affected parts of the world are the developing countries located in tropical and subtropical areas. Some examples of neglected vector-borne diseases include dengue/dengue hemorrhagic fever, human African trypanosomiasis (sleeping sickness) and onchocerciasis (river blindness).

It is projected that climate change will cause the spread of vector-borne diseases, and place additional stresses on ecosystems, thus bringing untold suffering to the rural poor, those in urban slums or in conflict zones. The most vulnerable in the population are the elderly, the young, the socially isolated, lower socioeconomic status families, those with preexisting conditions and the Immunocompromised (Having an immune system that has been impaired by disease or treatment).

» Read more: Climate Change and the Spread of Vector-Borne Diseases

Four Unexpected Impacts of NTDs

September 16th, 2010

By: Alanna Shaikh

We all know the obvious effects on neglected tropical diseases. Sickness, death, loss of economic productivity. A drag on the health system and governments in general. But the impact of the NTDs is deeper and more insidious than that – they affect every aspect of life in some developing nations. So, without further ado, I present – four unexpected impacts of the NTDs:

1. Higher Fertility rates

Most of the neglected tropical diseases are hardest on children; kids bear the brunt of the sickness and death that they cause. As a result, parents grow to expect that their children will frequently sicken and occasionally die. So, they have more kids, just to make sure they have some who survive to adulthood. Countries which have endemic NTDs also have higher fertility rates.

Higher rates of fertility, in return, are hard on the health of mothers, children, and families. Which makes them more vulnerable to NTDs. It’s an ugly cycle.

» Read more: Four Unexpected Impacts of NTDs