Posts Tagged ‘research’

Smallpox Eradication Taught Us How to Fight Polio: Now We Need to Win the Battle

August 27th, 2010

Reprinted with permission from Foundation Blog, The official blog of the Bill & Melinda Gates Foundation

By: Dr. Tadataka Tachi Yamada

When I was growing up in Japan, my close friend Keichi Maruyama, who lived right next door to me, was crippled from polio.

Most people today are too young to remember, but it was a disease that struck fear into every family. We knew it could hit home at any time.

Dr. Tadataka Tachi Yamada watches as a boy receives a polio vaccination at Bhairon Mandir Temple. Tachi was there to understand the importance of transit and migratory populations in contributing to polio transmission. New Delhi, India. April 5, 2009. Photo courtesy of the Bill & Melinda Gates Foundation / Prashant Panjiar.

Polio is no longer a threat in most of the world, thanks to a polio vaccine and an enormous global commitment. We are now locked in a mortal battle to completely eradicate the disease and have reduced the fight to just four countries – Nigeria, India, Afghanistan, and Pakistan.

This week I attended a symposium to commemorate the 30th anniversary of smallpox eradication. Thanks to the development and delivery of a vaccine, we achieved one of the greatest global health victories of all time. Vaccines are the most important and cost-effective intervention available to prevent illnesses and death.

I believe the fundamental lessons from smallpox can be applied to many diseases, especially the fight against polio. We need political will, sufficient human and financial resources, and ongoing scientific innovation

Of course there will be challenges along the way. I think the biggest lesson from the smallpox success is that we must approach each new challenge with the spirit of continuous learning and be flexible enough to adjust along the way. We must do the same until the world is polio-free, so that our children’s children will never have to say: “You came this close and gave up.”

Dr. Tachi Yamada, president of the foundation’s Global Health Program, leads the foundation’s efforts to help develop and deliver low-cost, life-saving health tools for the developing world. He oversees Global Health’s grantmaking, which focuses on four major activities: discovery, development, delivery, and advocacy.

Lessons Learned from Smallpox – When Eradication is the Goal, One Case is One Too Many

August 26th, 2010

Reprinted with permission from Foundation Blog, The Official Blog of the Bill & Melinda Gates Foundation

By: Walt Orenstein

I will never forget March 16, 1975.  It had been almost four months since I began working in India’s largest state, Uttar Pradesh (UP), to try to eradicate smallpox. 

On that morning, I was contacted about a new case of smallpox.  I reached the patient about 1 ½ hours after she died from an unusual complication, late hemorrhagic smallpox.  Her name was Shanti, a 7 month old child, the daughter of Pyari Lal. She was probably infected by her sibling.  Her death was totally preventable, but fortunately she turned out to be the last case of smallpox in UP.

We finally broke the human chains of transmission of that terrible virus.  That experience in India taught me how serious vaccine preventable diseases could be and how powerful vaccines are in preventing these types of tragedies.

Walter A. Orenstein, M.D doing community outreach in Aligarh, Uttar Pradesh, India during the successful 1975 smallpox eradication campaign. Photo Credit: Bill & Melinda Gates Foundation

The eradication of smallpox showed that effective vaccines can lead to the ultimate goal: the permanent end of a serious affliction of humankind. Smallpox eradication is our generation’s gift to all future generations. » Read more: Lessons Learned from Smallpox – When Eradication is the Goal, One Case is One Too Many

Reading List 8/25/2010

August 25th, 2010

A great new list of reads to get you through the week! Today we’re reading about a Lancet seminar on lymphatic filariasis and onchocerciasis, a great overview of drugs available to treat NTDs, Merck’s provision of funds to fight against HIV/AIDS in Botswana, and the use of roundworm in a new groundbreaking study. Enjoy!

Lancet seminar: lymphatic filariasis and onchocerciasis, NeLM news service
Medications to Treat Human Worms, Amy O’Connell, Live Strong
Merck Provides New Funding to Fight HIV/AIDS in Botswana, PharmaLive
Study of cell division sheds light on special mechanism in egg cells, Lab Spaces

Latest Lancet Article Reveals: “Africa is Desperate for Praziquantel”

August 13th, 2010

 

Urine samples from school-aged children from Nérékoro in Ségou region of Mali. Three samples on right show visible haematuria, which indicates infection with S haematobium. Three samples on left are not haematuric at visual inspection but could still contain abnormal number of red blood cells. Urine cloudiness (third sample from left) is early sign of abnormality. Photo Credit: The Lancet

In an editorial in the August 13 edition of The Lancet, authors representing the Sabin Vaccine Institute, the World Health Organization (WHO) and the Imperial College of London call for increased supplies of praziquantel for the African continent.  Praziquantel is the only commercially available treatment for human schistosomiasis, a devastating neglected tropical disease (NTD) affects an estimated 200-600 million people worldwide, with the vast majority of cases occurring in Africa, and causes chronic anemia and inflammation associated with severe disability among children, adolescents and young adults. Schistosomiasis produces a disease burden that could exceed that of malaria.

NTDs are devastating, disabling and debilitating parasitic and bacterial infections that adversely affect the poorest 1.4 billion people worldwide living on $1.25 a day. Such conditions promote poverty because of their impact on child growth and development, pregnancy outcome, and worker productivity, all of which adversely impact the earning capacity of already impoverished individuals and communities.

Authors Dr. Peter Hotez (Sabin Vaccine Institute), Dr. Lorenzo Savioli (WHO), Dr. Dirk Engels (WHO) and Dr. Alan Fenwick (Imperial), emphasize that because an estimated one billion tablets are needed to treat 400 million people annually or every other year, at least 10-20 times the currently donated praziquantel is necessary to increase treatment for schistosomiasis in Africa.

The authors conclude by stating that, “… praziquantel is urgently needed for sub-Saharan Africa now, and the current failure of the global community to provide access to this essential medicine is impeding sustainable development in Africa. The shortages of praziquantel should be treated as an African humanitarian crisis.”

 Read the full article here 

 

Good News For Buruli Ulcer

August 11th, 2010

By: Alanna Shaikh

I like good news, and this week has sure been short on it. Today, for example – we have added massive landslides in China to the floods in Pakistan and the forest fires in Russia. We could all use a good success story with interesting implications and – hey – I’ve got one:

The Stop Buruli consortium has successfully gene sequenced the bacteria that transmit Buruli. Buruli ulcer, for the unfamiliar, is a disgusting flesh-eating disease that leads to open sores and deformities. It generally affects children and young people, and it’s primarily found in West Africa (though it also shows up in Asia, Latin America, and Australia. I am hoping they mean some part of Asia far away from Central Asia, where I live.) And – this is fun – we’re not sure exactly how it is transmitted.  It has a mechanism beyond just skin-to-skin contact. It seems to be linked to slow moving water. Maybe.

» Read more: Good News For Buruli Ulcer

Gates Foundation Transitions The Living Proof Project to ONE

August 5th, 2010

Today the Bill & Melinda Gates Foundation made an important announcement.  A special project they launched, ‘The Living Proof Project: U.S. Investments in Global Health Are Working’ will now transfer over to the ONE Campaign.

The Living Proof Project was initially concieved to demonstrate successes in global health interventions worldwide. By sharing captivating stories of hope through a wide range of multimedia platforms, “Living Proof”emphasized that targeted interventions do save and improve lives afflicted by poverty and disease.

According to the official press announcement:

“ONE will expand The Living Proof Project to reach new audiences in more countries around an expanded set of development issues, including agriculture and access to clean water. ONE will also broaden The Living Proof Project beyond the U.S. to highlight the impact of European investments. The launch of this effort will include an event in London this fall featuring Bill and Melinda Gates. ONE will also collaborate closely with organizations working on the ground in developing countries to get the word out about the work they are doing to save lives and create opportunity.

With 2 million members globally and a record of creating cutting-edge advocacy campaigns, ONE will lead the next evolution of The Living Proof Project. ONE and its partners will incorporate The Living Proof Project content into their ongoing efforts to inspire and challenge people around the world to help secure long term, sustainable support from G8 and G20 nations for international development.”

We are excited by this news and look forward to seeing the dynamic ways that ONE will shape “Living Proof!” We also look forward to sharing and highlighting stories of optimism and progress here on End The Neglect!

Reading List 8/3/2010

August 3rd, 2010

Hello readers! Today’s reading list includes two articles focused on the ongoing flood in North West Pakistan, and the serious health risks posed by mass water contamination; promising breakthroughs in work on the hookworm vaccine made in New Zealand; and Congressman Hank Johnson’s (D-GA) proposed bill “Neglected Infections of Impoverished Americans Act 2010” which strives to tackle the growing problem of parasitic diseases in the United States.  Check out the links below:

Aid Begins to Trickle in to Flood-Ravaged Northwestern Pakistan, Griff Witte, The Washington Post

Pakistan’s Floods Leaves Millions Displaced, Johnathan Miller, PBS News Hour

NZ Research Targets Lungs for Hookworm Immunity, Otago Daily Times

Rep. Johnson Proposes Bill to Deal with Neglected Infections of Poverty, politicalnews.me


Scientists in the Role of Advocates: Fashion leads the way

August 2nd, 2010

by: Dr. John Wecker, PATH

A makeshift fashion runway. Pulsating music. The flash of strobe lights. The softness from a fog machine.  And a dozen leading pediatricians, scientists, and government officials modeling the latest in Filipino designer fashion wear. 

That was the scene from an evening gala event at the recent 2nd Asian Vaccine Conference (ASVAC) in Manila, Philippines. It was event intended to inject some levity after a long day of lectures and presentations, and to introduce the audience to an important aspect of Filipino culture (I have come to learn that Filipino women have a strong sense of cultural identity expressed through designer fashion). 

Beyond the haute couture, the willingness of these highly accomplished women (and one man) to model designer clothing in front of their colleagues and mentors is an expression of their confidence to move to a place others might find uncomfortable. This willingness to step out of safe boundaries, to go beyond where one’s professional training dictates, will be critical if we are to achieve the challenge set forth this year at ASVAC: Every Vaccine for Everyone:  Ensuring Equity. This is a challenge that can only be overcome if scientists join their voices in vaccine advocacy.

» Read more: Scientists in the Role of Advocates: Fashion leads the way

Calling all Global Health/Development Bloggers!

July 26th, 2010

 “End the Neglect,” the official blog for the Global Network for Neglected Tropical Diseases is looking for blog contributions from professionals and students in the global health/development field.

The Global Network launched the “End the Neglect” blog to serve as a broad, transparent platform through which we as a community can continue to raise the profile of neglected tropical diseases (NTDs) and disseminate stories from the field. End the Neglect is a vital education resource that informs readers of the devastating impact of NTDs and the simple and cost-effective interventions available.

While “End the Neglect” specifically focuses on NTDs, we are also interested in highlighting bloggers with a broader global health perspective. Success stories, personal stories/testimonials from the field, photos, and video are all welcome!

We accept submissions on a rolling basis. If you are interested in blogging for us, please send a writing sample of no more than 500 words and a brief background of your work/educational experience to Anjana.padmanabhan@sabin.org.

Our blog post submission guidelines are as follows:

  • Keep length of posts between 200-500 words
  • Include links to sites or articles that supplement your topic
  • When quoting other blogs or publications in your post, please link to the original material if possible, and denote quoted material using quotation marks.
  • Submit a brief biography (2-3 lines) and a photo for inclusion with your post.
  • We appreciate suggestions for images to accompany posts. If you have photos available for publication, please submit them along with your post and include caption information and attribution information.
  • If you don’t have images available, we will add one from our own photo stocks or from publicly available resources including Flickr or the CDC’s Public Health Image Library
  • We encourage you to email your post to colleagues and friends to encourage comment and discussion
  • Publication of posts is at the discretion of the Global Network, based on relevance of the subject matter as related to neglected tropical diseases and other global health issues.

Please review the guidelines for submissions below, and contact Anjana.Padmanabhan@sabin.org for more information. Please also visit us on Twitter and Facebook

Recent NTD Control Program Annual Meeting in Rwanda Brings Together Major Global Health Players

July 23rd, 2010
Kigali, Rwanda — The Ministry of Health, in partnership with Columbia University’s Access Project, organized the Neglected Tropical Diseases (NTDs) 2010 annual workshop, which was held at Laico Umubano Hotel on July 20, 2010. The objective of the meeting was to share the achievements accomplished by the NTD Control Program since its inception 3 years ago and to discuss the integration of the NTD Control Program strategies into existing initiatives.
The permanent secretary of the Ministry of Health, Dr. Agnes Binagwaho, launched the workshop by applauding the program’s impressive achievements over the past 3 years.
“We are happy with all the achievements in the fight against intestinal worms and bilharzias in Rwanda, but together with our stakeholders invited to this workshop, we are expecting to come up with strong program implementation strategies and discuss the feasibility of successfully integrating the program into existing initiatives” she said.
The NTD Control Program’s first activity was conducting a national assessment on the five most important NTDs in Rwanda, namely soil transmitted helminths (STHs), schistosomiasis, lymphatic filariasis and onchocerchiasis.