Drug discovery is by definition slow and costly. The multiphase process, which begins with basic science research and ends with clinical trials, can consume up to two decades and more than a billion dollars.
For NTDs such as African sleeping sickness and Chagas disease, the outlook is even grimmer: anti-infective drugs tend to have higher fail rates than other drugs, as parasites quickly develop resistance. And since NTDs predominantly affect low-income populations, the incentive for big pharmaceutical companies to improve on current treatments is low.
But current treatments are ghastly. In some cases, the drugs themselves can be poisonous and have high mortality rates. With one-third of the planet’s population at risk for NTDs, a new paradigm is required.
Northeastern University chemistry and chemical biology professor Michael Pollastri believes an open-source science model will hasten the drug discovery process. Despite great advances in NTD research over the last decade, the global research effort is largely uncoordinated. Continue reading