Category Archives: elephantiasis

Nobel Prize Awarded to Scientists Who Discovered NTD Medicine

LF-Nobel-Blog

Rabi, who suffers from LF, and his children, Sanjay and Mamali, in Ganjam District, Odisha, India. Photo: Naveen Pun / Global Network for NTDs

Today the Nobel Prize in Physiology or Medicine was awarded to two scientists for the discovery of a drug that treats two common neglected tropical diseases (NTDs).

William Campbell and Satoshi Ōmura were honored for their work developing a new class of anti-parasitic drugs. The prize was shared with Tu Youyou for her discovery of a new malaria drug. The Nobel committee noted, “The global impact of their discoveries and the resulting benefit to mankind are immeasurable.”

Ōmura isolated a promising soil bacteria he found in a Japanese golf course, from which William C. Campbell discovered a component that proved remarkably effective against parasites. The component, named Avermectin, was subsequently chemically modified to be even more effective and called Ivermectin.

Her grand-daughter Adamsay Turay, 8, helps Lucy Bangura, walk in the town of Masongbo, Sierra Leone on Thursday July 12, 2012.

Her grand-daughter Adamsay Turay, 8, helps Lucy Bangura walk in the town of Masongbo, Sierra Leone on Thursday July 12, 2012. Photo: Oliver Asselin / Global Network for NTDs

Great progress has been made through annual mass treatment with the drug. Last year, more than 270 million treatments were donated to people in impoverished communities to treat onchocerciasis (also known as river blindness) and lymphatic filariasis (or elephantiasis). Some areas are now close to interrupting transmission and eliminating these two devastating NTDs which lead to blindness and debilitating swelling.

We celebrate the scientific discovery that made this possible and honor and applaud the efforts of all those who contribute to the fight against NTDs — from the companies that donate the medicine and the community volunteers who distribute it to the donors who sustain these programs.

After the discovery of the bacterial compound, it took decades to mass produce and secure the donation of Ivermectin. But in the next five years we can protect millions from onchocerciasis and eliminate lymphatic filariasis around the world by ensuring those in need have access to this Nobel Prize-winning drug.

TAKE ACTION: Please donate now to help us raise awareness, funding and political commitments to make sure NTD medications reach those in need.

Celebrating NTD Success Stories: Good News from Haiti

Emily Conron speaks with patients in Haiti suffering from chronic filarial lymphedema.

Emily Conron speaks with patients suffering from lymphatic filariasis in Haiti

During the month of October, END7 student supporters are celebrating NTD Success Stories — spreading the exciting news that many countries around the world have already made incredible progress towards the control and elimination of some NTDs. In recent weeks, there have been many new successes to celebrate, like the announcement two weeks ago that Mexico has become the third country to officially eliminate river blindness, and the exciting news Monday that William Campbell and Satoshi Omura were awarded the Nobel Prize in medicine for their discovery of ivermectin, a drug used to treat and prevent onchocerciasis and lymphatic filariasis. This month, in addition to these exciting announcements, we want to highlight four countries — Haiti, India, Sierra Leone and the Philippines — that have achieved success fighting NTDs. Each country has overcome their own challenges, ranging from earthquakes to the Ebola epidemic, to make sure communities receive the medicine they need. We think these stories help communicate not just the scope of the suffering caused by NTDs, but the hope we have of ending these diseases for good.

The poorest country in the Western hemisphere, with the highest infant mortality and lowest life expectancy, Haiti is a country with many challenges. But the story of Haiti’s success against NTDs is a powerful reason for hope. Nearly the entire population is at risk of contracting lymphatic filariasis (LF), a mosquito-borne NTD. Caused by thread-like filarial worms that live in the lymphatic system, LF causes painful swelling of the extremities (a condition known as elephantiasis) and genitals (a condition known as hydrocele). The high prevalence of NTDs like LF persists, in large part, because of poor access to water and sanitation. About nine out of ten Haitians in rural areas do not have access to clean, safe water, and almost half lack access to adequate sanitation facilities. These circumstances were compounded in the wake of the 2010 earthquake that killed at least 200,000 people and destroyed much of the nation’s infrastructure. Despite these challenges, Haiti is making incredible progress against NTDs and expanding its national NTD control program with the goal of eliminating LF for good.

Under the leadership of the Haitian government, a range of partners have assisted with the annual distribution of drugs to help prevent the spread of four NTDs: LF, whipworm, hookworm and roundworm. A critical aspect of the success of these efforts has been the training of more than 30,000 local community leaders to organize, promote and carry out mass drug administration (MDA), distributing medicine to everyone in at-risk communities.

Until the 2010 earthquake, Haiti’s Neglected Tropical Disease Control Program conducted MDAs only in the areas of the country where LF was most prevalent. The crowded capital city of Port-au-Prince, with relatively low levels of LF infection, was thought to be too difficult a setting to carry out MDA. But after two million people were left homeless following the earthquake, internal migration threatened to redistribute the disease. The Haitian government then decided to focus on national MDA coverage, with the aim of completely eliminating the disease and preventing redistribution.

By late 2011, at least one round of MDA had been conducted in all endemic areas of Haiti except the capital, Port-au-Prince. From November 2011 to February 2012, an MDA was conducted for the first time in the crowded metropolitan area. More than 80% of the population has now been reached with NTD medications, a tremendous accomplishment in a country facing many health and development challenges. In May of 2014, the U.S. Agency for International Development (USAID), a major partner of the Haitian government’s NTD program, delivered its one billionth treatment worldwide at a ceremony in Saint-Louis-du-Sud, Haiti, a testament to the country’s commitment and progress in the fight against NTDs.

Haiti is also an example of an integrated approach to combating NTDs, having successfully integrated its LF and soil-transmitted helminth (STH) control programs, which previously operated in separate units at the Ministry of Health. To supplement expanded MDA efforts, the country is also scaling up efforts to address the needs of Haitians already incapacitated by LF and to fortify table salt with medicine to prevent LF, an approach that has helped countries like China eliminate the disease. These efforts are supported by dedicated partners including the Pan American Health Organization, the Inter-American Development Bank, the U.S. Centers for Disease Control (CDC), USAID, the University of Notre Dame Haiti Program, IMA World Health and CBM.

Haiti is one of just four countries in the Americas where LF remains endemic, accounting for 80% of people at risk of the disease in the region. If the country can succeed in their effort to eliminate LF by 2020, it would be a major milestone in global efforts to end the disease. As Dr. Patrick Lammie, an immunologist with the CDC, told NPR, “If a country like Haiti, with all of the challenges that they’ve faced over the last few years, is able to achieve full national coverage, I think that is an important example for other countries, which are struggling to scale up their programs as well.”

Certainly, a country that has not just maintained, but expanded efforts against NTDs in the face of political instability and crippling natural disasters is a powerful example to the rest of the world. Haiti’s success demonstrates the power of country ownership, government leadership, partnerships and integrated and holistic public health programs in the fight against NTDs.

END7 supporters are excited to celebrate Haiti’s unfolding success story, a narrative of perseverance in the face of challenges — and the first of four inspiring NTD Success Stories in a month that’s already offered many reasons to celebrate!

World Health Day: The neglected diseases that plague 1 in 6

WHDToday is World Health Day, and the global community is calling attention to the immense harm caused by diseases spread by  mosquitoes, sand flies and snails — also referred to as vector-borne diseases.

As part of this effort, Global Network managing director, Neeraj Mistry, highlighted the debilitating effect of neglected tropical diseases (NTDs) in a CNN editorial.

“Human history is closely linked to diseases carried by vectors such as the sand flies at the heart of blinding and disfiguring diseases referenced during biblical times, fleas responsible for bubonic plague in Medieval Europe, and the mosquitoes that carry one of today’s most well-known diseases, malaria.

What most people don’t know, however, is that there are several other vector-borne diseases that have a staggering impact on the world’s poorest people. Called neglected tropical diseases, or NTDs, this group of parasitic and bacterial infections plagues one in six people worldwide, including more than 500 million children.”

To read the full editorial, click here. You can spread the word on Twitter by using the hashtags #WorldHealthDay and #JustOneBite.

 

How You Contributed to the Movement against NTDs in 2013 – and How We Can Do Even More

 

As 2013 comes to a close, we have reason to celebrate. END7 supporters helped treat entire communities of people suffering from neglected tropical diseases (NTDs) in Honduras, Myanmar, and Kenya, and our partners have completed treatment programs for millions of people in other countries. We’re making progress in the fight against NTDs.

The hundreds of thousands of children, mothers, families and communities who benefit from NTD treatment motivate us to continue the fight; mothers like Alice who pray every day for the health of their families, and sisters like Neema who want to be healthy and free of parasites so they can play and learn with their siblings.

Watch our new video to see the people who are benefitting from our work. We want to say thank you for making a difference in their lives.

The effort to end NTDs includes a diverse group of global partners, including the World Health Organization (WHO), national governments, pharmaceutical companies, corporations and individuals. Just this year, world leaders took notice and stood up for the 1.4 billion people suffering from NTDs.  The World Health Assembly, the African Union and the Organization of America States all made commitments to end NTDs. Governments across the world made national plans to end NTDs within their own countries — and when so many END7 supporters spoke out on behalf of those suffering from  NTDs, the United Nations responded with a letter stating that the fight against NTDs is “paramount to the global efforts to eradicate poverty.”

We’ve come a long way, but we can do even more in 2014 with your help. We’re ready to expand our efforts next year and reach even more communities in more countries. Your donations help deliver medicine to hard to reach places, train healthcare workers to administer treatment, educate people about NTDs, prepare for annual pill distributions and help communities take ownership of their own treatment programs.

If we want to improve the health of the most marginalized communities, enhance economic performance and contribute to broader development goals, we need to press on in the fight against NTDs. Will you stand with us? Donate, or start your own campaign to amplify our efforts and improve the lives of those who need it most.