Tag Archives: mectizan

Venezuela Interrupts Transmission of Onchocerciasis in North-Central Region

Venezuela has successfully interrupted the transmission of onchocerciasis in the north-central region of the country. Using its National Onchocerciasis Elimination program, the country distributed ivermectin throughout the region over a course of seven years (2003-2007). The program was implemented with the goal of interrupting transmission within the region by 2012. Read more about this breakthrough in the fight against NTDs on the Pan American Health Organization’s (PAHO) website.

Photo Courtesy of PAHO

Reading List 7/9/2010

Happy Friday! A short reading list today to send you off to a relaxing weekend. Today we’re reading about new drugs being investigated that would treat both tuberculosis and NTDs, prevalence of urinary schistosomiasis in pre-school children in Nigeria, and the amazing effects of Mectizan on river blindness.

Potential TB Drugs Investigated Against Multiple Neglected Diseases, Medical News Today
Urinary schistosomiasis in pre-school kids in Nigeria, Robert Herriman, The Examiner
Miracle Medicine Mends Nigerian Tailor’s Eyesight, The Carter Center

Can large scale disease control programs be sustained?

Reprinted with permission from: Malaria Free Future

By: Bill Brieger

Roll Bank Malaria (RBM) was launched in 1998, but actual scale up to universal coverage is only happening in 2010. By Comparison, the African Program for Onchocerciasis Control (APOC) took off in 1996 and has been scaled up for several years in all but a few of its endemic countries. Granted, APOC has a relatively smaller target area, but it now regularly reaches over 127,000 African villages with annual doses of ivermectin.

Both programs have in common the need to sustain their scaled up for many years into the foreseeable future if disease elimination is to be achieved.

This need for a long term perspective causes concern when one reads about a threat to continued funding for APOC’s Borno State, Nigeria project, and raises speculation whether malaria efforts may face the same threat a few years down the line.

Photo Courtesy of http://www.malariafreefuture.org/blog/?p=972

APOC started with a very clear vision of sustainability. APOC, a government entity (state, province, district, or country) and a non-governmental development agency (NGDO) would enter into a financial and programmatic 5-year partnership to establish community directed treatment with ivermectin (CDTI – see photo of CDTI in Cameroon at right). APOC’s financial contribution would be largest in the first year, when the overall budget would be largest because of start up costs.

Over time, program costs were to reduce, as would costs per person treated because of economies of scale. APOC’s share of the budget would decrease relative to that of the government partner, though the overall budget to maintain the program into the future was expected to be smaller and more manageable to the government partner with some continued support from the NGDO.

Free supplies of ivermectin from the Mectizan Donation Program would continue as long as there was need, but by the sixth year of operation, it was hoped that countries could sustain their own CDTI efforts. Apparently this has not been easy.

Evidence of problems with Borno’s CDTI project surfaced in 2007 at a meeting of APOC’s Technical Consultative Committee where the following report was shared. “Borno has maintained a good geographic and therapeutic coverage. However, the project has the following challenges:

* Non-release of funds by state and LGAs
* Inadequate number of FLHF staff
* Selection and training of more CDDs
* Obtaining funds from the government

IRIN now reports that after 11 years of operation “The (Borno State) government was supposed to provide counterpart funds to run the river blindness programme, but it has not done so, (according to) Borno State’s onchocerciasis coordinator Galadima.” Hellen Keller International (HKI) is Borno’s NGDO partner for CDTI and has been trying to make up the slack.

Unfortunately “HKI funding has been hit by the global recession, says (a representative). ‘Since the recession our donors have turned their attention elsewhere with little consideration for Africa and this affects the volume of funds for intervention projects like the onchocerciasis.’

Project staff complained to IRIN that, “We have been crippled financially due to lack of state counterpart funding. We sometimes find it hard to fuel our vehicles and go for supervision in the affected communities.”

There were hopes that another four years of government funding would put Borno within reach of elimination goals, but project staff lament that, “If the project stops at this stage, the effects will be devastating. It will turn the tide of the success we have achieved which will be quite disastrous.”

Let’s move this scenario forward to 2015 and change the disease to malaria. Let’s assume that talk of funding ceilings by donors has become a pressing reality and countries need to contribute more to sustain malaria interventions and achieve elimination. Let’s hope we don’t wind up again like malaria control did in the 1950s and ‘60s – eliminating the programs, not the disease.

PS – The IRIN article does have some potential technical problems. It referred to the CDTI as a program to create ‘immunity’ to onchocerciasis, whereas ivermectin actually is a drug to kill the microfilaria of the parasite and keep infection at a low level until such time as adult worms die and transmission in the community stops. There is also concern about the figure of $18 per person treated. Normally at this advanced stage of the program we should be talking in terms of cents, not dollars. These technical problems with the article do not detract from its serious financial message.


Bill Brieger is currently a Professor in the Health Systems Program of the Department of International Health at Johns Hopkins University as well as the Senior Malaria Adviser for JHPIEGO, JHU’s family and reproductive health affiliate. He was a Professor in Health Education at the African Regional Health Education Centre, University of Ibadan, Nigeria, from 1976 to 2002. His research interests have focused on the social and behavioral aspects of tropical disease control, and in the area of malaria research, funded by the Unicef/UNDP/World Bank/WHO Tropical Disease Research program (TDR) and USAID implementing partners, this has included acceptability of pre-packaged antimalarial drugs, urban malaria, role of patent medicine sellers in malaria treatment, and community and cultural perceptions of malaria as a basis for village health worker training and health education.

More on Onchocerciasis: An Expert’s Perspective

By Dr. Adrian Hopkins, Director, Mectizan Donation Program

River Blindness, or to give it its medical name, Onchocerciasis, is a devastating disease where it is highly prevalent and people are exposed just by living in the area.

In 1993 I was seconded by CBM to work as the Technical Advisor to the Central African Republic government for the national Onchocerciasis Control Programme and blindness prevention programme. Based in the NW of the country, where the disease is most prevalent, proved to be an unforgettable experience. Villages along the Ouham River were full of people who were blind or partially sighted, people suffering from epilepsy and everyone had continuous itching.  In one village half the adult population were blind or visually impaired.  Children, who should have been at school, were being robbed of their childhood having to constantly lead around a parent. Everybody was scratching due to unrelenting skin irritation. Not only were everyday lives a misery but people died much younger as a result. In one “Sentinel Site” where we examined everyone in the village for the parasite, and for eye and skin disease, I discovered that there were only two people older than myself in the whole village and I was still in my forties!

oncho

A blind village chief in NW Central African Republic with his children

What a difference Mectizan made to these communities.  Because these people were highly infected Mectizan caused some reactions due to the massive destruction of parasites in the skin. Visiting one village a month after the treatment I was worried by their descriptions of their reactions, severe itching (worse than usual) joint pains, fever, swellings I was told I had made them ill for three weeks.  I asked with trepidation if they would take Mectizan next time round.  There was no hesitation and the answer was 100% positive. Why I naively asked? Because after three weeks of suffering, getting rid of our worms, we have never felt better in our whole lives, we can work harder and enjoy life so much more!

How sad that in areas like these civil unrest has prevented the regular treatment in the last few years and instead of being on the verge of eliminating the disease the population face the possibility of a return to the situation in the early 1990s.

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