Posts Tagged ‘onchocerciasis’

Reading List 8/25/2010

August 25th, 2010

A great new list of reads to get you through the week! Today we’re reading about a Lancet seminar on lymphatic filariasis and onchocerciasis, a great overview of drugs available to treat NTDs, Merck’s provision of funds to fight against HIV/AIDS in Botswana, and the use of roundworm in a new groundbreaking study. Enjoy!

Lancet seminar: lymphatic filariasis and onchocerciasis, NeLM news service
Medications to Treat Human Worms, Amy O’Connell, Live Strong
Merck Provides New Funding to Fight HIV/AIDS in Botswana, PharmaLive
Study of cell division sheds light on special mechanism in egg cells, Lab Spaces

Reading List 8/23/2010

August 23rd, 2010

Happy Monday readers! A new list of reads for your reading pleasure. Today we’re reading about one man’s dedication to eliminating onchocerciasis within his community in Uganda, how intestinal worms could be used as a treatment for Crohn’s disease, the Public Library of Science’s launch of the new open-access journal on NTDs, and a few of the latest articles on the flooding disaster in Pakistan.

Ugandan Man Helps Rid His Community of Onchocerciasis, Carter Center
Can Intestinal Parasites Help Crohn’s Disease?, Mary Desaulniers, AutoImmuneDisease
PLoS ONE is launched by the Public Library of Science, Bio-Medicine
Pakistan flood donations top $26m, The Press Association
Struggle for food as Pakistan floods worsen, Sally Sara, ABC News

Are Certain Global Health Initiatives Disrupting Basic Medical Care In Poor Countries?

August 19th, 2010

Women outside clinic in Gashora, Rwanda. Photo: Lindsay Wheeler

It’s hard to argue against the fact that there are many global health interventions that can go a long way toward the control and elimination of  many neglected tropical diseases (NTDs). Global health initiatives have become an intrinsic part of international aid policy.

At a low financial cost, single disease campaigns  in various countries like Rwanda, Burundi, Mali and Sierra Leone for instance, have seen success in deworming children and treating patients for schistosomiasis, onchocerciasis, and trachoma.

» Read more: Are Certain Global Health Initiatives Disrupting Basic Medical Care In Poor Countries?

Hope & protection against blinding disease delivered to millions

July 27th, 2010

This month marks the 150 millionth treatment against river blindness by international development NGO Sightsavers. Since 1987 when pharmaceutical company Merck & Co., Inc. took the pioneering decision to donate Mectizan® (ivermectin), the treatment that had been shown to effectively and safely treat onchocerciasis (also called river blindness), Sightsavers has been working with its partners to tackle this neglected tropical disease (NTD) and ensure that it is eliminated as a threat to some 120 million people worldwide, 99 percent of whom live in Africa. Sir John Wilson, who founded Sightsavers 60 years ago and was himself blind, first noted the devastating effects of the disease for himself when he visited Ghana in 1947, and coined the name “river blindness” to describe it. Sightsavers was then involved in the first groundbreaking research into this NTD and has since become a world leader in this field.

» Read more: Hope & protection against blinding disease delivered to millions

Millions and Billions

July 26th, 2010

Photo Credit: Lindsay Wheeler

By: Tara Hayward, Resource Development Officer, Sabin Vaccine Institute

The economy has started to thaw and donors of the world are beginning to relax. Bill and Melinda Gates, along with Warren Buffett, have a launched an epic challenge for the world’s billionaires – Give away half of what you have.  While The Giving Pledge is specifically focused on billionaires, it feeds on inspiration from philanthropic efforts that encourage everyone – of all financial means and backgrounds. We all can help make the world a better place, right?

In the context of all the millions and billions of dollars floating around, as donors, we naturally start to wonder if we can do anything, if we can make any impact with a $20 donation to our favorite cause. The answer? Yes!

» Read more: Millions and Billions

Reading List 7/20/2010

July 20th, 2010

As the 8th Annual International AIDS Conference takes place in Vienna, Austria this week, we would like to highlight some articles with news on HIV/AIDS. Today we’re reading about the push for more HIV/AIDS funding, the increasing new cases of HIV, and the increase in number of individuals receiving HIV treatment. And of course, we also threw in a couple articles about NTDs as well! Enjoy.

Leaders Weigh In On Global HIV/AIDS Funding, Medical News Today
Number of HIV-positive in treatment rose by a quarter last year, Chicago Tribune
More than five million people receiving HIV treatment, Webwire
Lymphatic filariasis: education leads to big increases in numbers who comply with treatment, Paul Chinnock
Uganda: Riverblindness Falls to 7 Percent, Eriosi Nantaba, All Africa

Reading List 7/9/2010

July 9th, 2010

Happy Friday! A short reading list today to send you off to a relaxing weekend. Today we’re reading about new drugs being investigated that would treat both tuberculosis and NTDs, prevalence of urinary schistosomiasis in pre-school children in Nigeria, and the amazing effects of Mectizan on river blindness.

Potential TB Drugs Investigated Against Multiple Neglected Diseases, Medical News Today
Urinary schistosomiasis in pre-school kids in Nigeria, Robert Herriman, The Examiner
Miracle Medicine Mends Nigerian Tailor’s Eyesight, The Carter Center

Can large scale disease control programs be sustained?

June 10th, 2010

Reprinted with permission from: Malaria Free Future

By: Bill Brieger

Roll Bank Malaria (RBM) was launched in 1998, but actual scale up to universal coverage is only happening in 2010. By Comparison, the African Program for Onchocerciasis Control (APOC) took off in 1996 and has been scaled up for several years in all but a few of its endemic countries. Granted, APOC has a relatively smaller target area, but it now regularly reaches over 127,000 African villages with annual doses of ivermectin.

Both programs have in common the need to sustain their scaled up for many years into the foreseeable future if disease elimination is to be achieved.

This need for a long term perspective causes concern when one reads about a threat to continued funding for APOC’s Borno State, Nigeria project, and raises speculation whether malaria efforts may face the same threat a few years down the line.

Photo Courtesy of http://www.malariafreefuture.org/blog/?p=972

APOC started with a very clear vision of sustainability. APOC, a government entity (state, province, district, or country) and a non-governmental development agency (NGDO) would enter into a financial and programmatic 5-year partnership to establish community directed treatment with ivermectin (CDTI – see photo of CDTI in Cameroon at right). APOC’s financial contribution would be largest in the first year, when the overall budget would be largest because of start up costs.

Over time, program costs were to reduce, as would costs per person treated because of economies of scale. APOC’s share of the budget would decrease relative to that of the government partner, though the overall budget to maintain the program into the future was expected to be smaller and more manageable to the government partner with some continued support from the NGDO.

Free supplies of ivermectin from the Mectizan Donation Program would continue as long as there was need, but by the sixth year of operation, it was hoped that countries could sustain their own CDTI efforts. Apparently this has not been easy.

Evidence of problems with Borno’s CDTI project surfaced in 2007 at a meeting of APOC’s Technical Consultative Committee where the following report was shared. “Borno has maintained a good geographic and therapeutic coverage. However, the project has the following challenges:

* Non-release of funds by state and LGAs
* Inadequate number of FLHF staff
* Selection and training of more CDDs
* Obtaining funds from the government

IRIN now reports that after 11 years of operation “The (Borno State) government was supposed to provide counterpart funds to run the river blindness programme, but it has not done so, (according to) Borno State’s onchocerciasis coordinator Galadima.” Hellen Keller International (HKI) is Borno’s NGDO partner for CDTI and has been trying to make up the slack.

Unfortunately “HKI funding has been hit by the global recession, says (a representative). ‘Since the recession our donors have turned their attention elsewhere with little consideration for Africa and this affects the volume of funds for intervention projects like the onchocerciasis.’

Project staff complained to IRIN that, “We have been crippled financially due to lack of state counterpart funding. We sometimes find it hard to fuel our vehicles and go for supervision in the affected communities.”

There were hopes that another four years of government funding would put Borno within reach of elimination goals, but project staff lament that, “If the project stops at this stage, the effects will be devastating. It will turn the tide of the success we have achieved which will be quite disastrous.”

Let’s move this scenario forward to 2015 and change the disease to malaria. Let’s assume that talk of funding ceilings by donors has become a pressing reality and countries need to contribute more to sustain malaria interventions and achieve elimination. Let’s hope we don’t wind up again like malaria control did in the 1950s and ‘60s – eliminating the programs, not the disease.

PS – The IRIN article does have some potential technical problems. It referred to the CDTI as a program to create ‘immunity’ to onchocerciasis, whereas ivermectin actually is a drug to kill the microfilaria of the parasite and keep infection at a low level until such time as adult worms die and transmission in the community stops. There is also concern about the figure of $18 per person treated. Normally at this advanced stage of the program we should be talking in terms of cents, not dollars. These technical problems with the article do not detract from its serious financial message.


Bill Brieger is currently a Professor in the Health Systems Program of the Department of International Health at Johns Hopkins University as well as the Senior Malaria Adviser for JHPIEGO, JHU’s family and reproductive health affiliate. He was a Professor in Health Education at the African Regional Health Education Centre, University of Ibadan, Nigeria, from 1976 to 2002. His research interests have focused on the social and behavioral aspects of tropical disease control, and in the area of malaria research, funded by the Unicef/UNDP/World Bank/WHO Tropical Disease Research program (TDR) and USAID implementing partners, this has included acceptability of pre-packaged antimalarial drugs, urban malaria, role of patent medicine sellers in malaria treatment, and community and cultural perceptions of malaria as a basis for village health worker training and health education.

Reading List 5/19/2010

May 19th, 2010

We’ve been getting a lot of interesting analysis and attention on Dr. Hotez’s New York Times editorial, along with his newly published NTD debate paper in PLoS Medicine that have both been released this past week. So on today’s reading list, we’ve provided you with a sample of what people are saying about the pieces and the engaging discussions that they have sparked. We’ve also included materials in other NTD and global health news, particularly about the decrease in deaths of children under five years old, and the importance of water sanitation. Enjoy!

Millions could be spared with funding increase, VOA News
Researchers Call for ‘Social Offset’ to Tackle NTDs, Science Daily
Neglected diseases: Teach or treat?, Megan Scudellari, The Scientist
WHO says under-5 deaths drastically reduced, Afrique en ligne
Nigeria: When Water Becomes a Curse, World News
South Africa: Benefits of Working Together on Water, Terna Gyuse, All Africa

The Forgotten Sick

April 27th, 2010

David Molyneux, former Director of the Liverpool School of Tropical Medicine and a founding partner of the Global Network, has written a commentary piece arguing for NTD treatment. The piece clearly summarizes the state of NTDs, why they need to be treated, and the hope for the future. Click here to give it a read.